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147. Resting-State Functional Connectivity of a Theory of Mind Network and Theory of Mind Decoding in Individuals With and Without Depression
Major depressive disorder is associated with poorer accuracy in decoding others’ mental states (i.e., theory of mind) relative to healthy comparison groups, which may provide the social-cognitive basis for interpersonal dysfunction in depression. Theory of mind decoding relies on activation of the temporo-parietal junction (TPJ), inferior frontal gyrus (IFG), and the left middle cingulate gyrus (MCG). However, it is unclear whether connectivity among these regions is associated with behavioural measures of theory of mind, or how this association differs between depressed and non-depressed groups. The present study explored differences between currently depressed (n = 45) and never-depressed (n = 22) adults in the relation between resting-state functional connectivity among the TPJ, IFG, and MCG and accuracy on a theory of mind task—the Reading the Mind in the Eyes task (RMET)—completed outside the scanner. Functional connectivity was defined as the co-activation of spherical regions of interest over time, captured using resting-state functional magnetic resonance imaging. Data analysis is in progress. We hypothesize that higher accuracy on the RMET will be associated with greater functional connectivity among the TPJ, IFG, and MCG, and that this association will be stronger for the never-depressed adults than for those in a depressive episode.