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Thirty-Third Annual Meeting of the Society for Research in Psychopathology

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147. Resting-State Functional Connectivity of a Theory of Mind Network and Theory of Mind Decoding in Individuals With and Without Depression

Major depressive disorder is associated with poorer accuracy in decoding others’ mental states (i.e., theory of mind) relative to healthy comparison groups, which may provide the social-cognitive basis for interpersonal dysfunction in depression. Theory of mind decoding relies on activation of the temporo-parietal junction (TPJ), inferior frontal gyrus (IFG), and the left middle cingulate gyrus (MCG). However, it is unclear whether connectivity among these regions is associated with behavioural measures of theory of mind, or how this association differs between depressed and non-depressed groups. The present study explored differences between currently depressed (n = 45) and never-depressed (n = 22) adults in the relation between resting-state functional connectivity among the TPJ, IFG, and MCG and accuracy on a theory of mind task—the Reading the Mind in the Eyes task (RMET)—completed outside the scanner. Functional connectivity was defined as the co-activation of spherical regions of interest over time, captured using resting-state functional magnetic resonance imaging. Data analysis is in progress. We hypothesize that higher accuracy on the RMET will be associated with greater functional connectivity among the TPJ, IFG, and MCG, and that this association will be stronger for the never-depressed adults than for those in a depressive episode.

Chloe C. Hudson
Queen's University

Scott D. Squires
Queen's University

Jordan Poppenk
Queen's University

Mojdeh Zamyadi
Rotman Research Institute, Baycrest Health Sciences

Stefanie Hassel
University of Calgary

Glenda MacQueen
University of Calgary

Stephen Strother
Rotman Research Institute, Baycrest Health Sciences

Roumen Milev
Queen's University

Sidney Kennedy
University of Toronto

Kate L. Harkness
Queen's University

 


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