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159. Investigating Distinct Neuroanatomical Correlates of Subdimensions of Antisocial Behavior
Antisocial behavior is a broad and heterogeneous construct which can be divided into two specific, but related dimensions: aggressive behaviors (AGG) and (non-aggressive) rule-breaking behaviors (RBB). Although these two dimensions reliably form a single externalizing dimension, research has demonstrated reliable distinct neurobehavioral processes associated with each. Using voxel-based morphometry, the current study examined unique structural gray matter (GM) correlates of AGG and RBB. Participants included 478 6-10 years olds (34.9% female; Mage= 8.45 ± 1.4 years), whose parents reported on AGG and RBB. Accounting for age, sex, total brain volume, IQ, RBB and AGG, respectively, AGG and RBB were examined as predictors of GM variation. Whereas no significant associations emerged for RBB, AGG was uniquely associated with a cluster located primarily in the precentral gyrus. Through the inclusion of attention problems (AP), post-hoc analyses considered whether the unique variance of AGG associated with the precentral gyrus was reflective of inhibitory control problems. Indeed, parallel to findings for AGG, results revealed an association between AP and a cluster in the precentral gyrus. Results suggest unique neuroanatomical correlates reflecting distinct neural pathways of separable antisocial behaviors in children with this distinction potentially reflecting inhibitory control deficits associated with AGG but not RBB.