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Linking RDoC constructs to HiTOP dimensions: a conceptual model and new findings
Since its inception, the Research Domain Criteria (RDoC) has sought to provide a new framework rooted in neuroscience to clarify the neurobiological bases of mental illnesses and, ultimately, inform their classification. More recently, the Hierarchical Taxonomy of Psychopathology (HiTOP) has proposed a dimensional classification with greater focus on the symptoms and structure of psychopathology, which promises to provide psychometrically-robust targets for research and improve clinical practice. Despite differences in approach, several similarities may be drawn between the mission and constructs proposed by these two frameworks. In this talk, we will outline the connections between RDoC constructs and HiTOP dimensions, based on comprehensive review of the existing literature. We will further present our recent work supporting these associations, using latent variable modeling of rich assessments of psychopathology, personality and dispositional traits, and neural (EEG) markers of affective, reward, and cognitive processes in a community sample of 550 adolescents. We will argue that using HiTOP dimensions as targets for research on RDoC constructs can facilitate progress in our understanding of the neural bases of psychopathology and help delineate a unified dimensional nosology.