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43. Optical Coherence Tomography of the Retina in Schizophrenia: Inter-Device Agreement and Relations with Perceptual Function
Studies have begun to assess retinal structural integrity in schizophrenia using optical coherence tomography (OCT) but show conflicting results. We utilized two OCT machines in order to assess consistency of results and assessed relationships between retinal structure and perceptual function. Participants in this pilot study were 12 individuals with schizophrenia spectrum disorders (SSD) and 12 age-matched controls. Visual function was assessed with low-contrast visual acuity (LCVA), the King-Devick (K-D) test that requires saccadic eye movements, and the Brief Visuospatial Memory Test Revised (BVMT-R). Results showed excellent relative agreement in OCT measurements between the two machines. SSD showed decreased macular volume on both machines but no difference in retinal nerve fiber layer (RNFL) or ganglion cell+inner plexiform layer (GCL+IPL) thickness compared to controls. Controls, but not patients, showed significant positive associations between K-D performance and RNFL thickness and macular volume, and between LCVA and GCL+IPL thickness. SSD showed a negative relationship between RNFL/GCL+IPL thickness and BVMT performance, which suggests that a neuroinflammatory process may have occurred. Consistent results showing macular changes provide further support for the retina as a “window to the brain” but further work is needed to understand conflicting results between studies.