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169. Temporal Experience of Pleasure in Schizophrenia: A Systematic Review and Meta-Analysis
Anhedonia, or the inability to experience pleasure, has long been recognized as a hallmark negative symptom of schizophrenia spectrum disorders (SSD). However, several quazi-experimental studies suggest that the ability to experience pleasure in the moment, termed consummatory pleasure, may be intact in SSD, while the ability to anticipate pleasure from future events, termed anticipatory pleasure, may be impeded. The Temporal Experience of Pleasure Scale (TEPS) was developed to separately assess trait anticipatory and consummatory pleasure. Although some studies employing the TEPS have found a compartmentalized anticipatory pleasure deficit in SSD, other studies have not. The current meta-analytic review sought to quantify TEPS-rated anticipatory and consummatory pleasure, as well as their comparative associations to one another, in patients with SSD relative to controls (k=26). Moderator analyses were also conducted to better understand the demographic and symptomatic impacts of SSD on patients’ TEPS scores. Counter to quazi-experimental findings of intact in-the-moment pleasure in SSD, patients demonstrated significant self-reported anticipatory and consummatory pleasure deficits, and there was no weighted mean difference between TEPS consummatory and anticipatory effect sizes. On average, both domains of TEPS-rated trait anhedonia were equally affected in SSD relative to controls. Alternative interpretations of these findings are discussed.