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1. Contribution of biological sex and social sensitivity to comorbid psychosis and cannabis use disorder.
Cannabis use (CU) is prevalent in individuals with early psychosis (EP) and associated with worsened prognosis. Prior literature indicates males endorsing CU at a younger age are more likely to develop cannabis use disorder (CUD). We hypothesize social factors (e.g., rejection sensitivity, social anxiety) increase CUD risk, particularly for males. 144 (62 female) EP and 48 (28 female) healthy control (HC) participants completed CU measures (CUPIT, DUSI-SU). A subset [26EP (14 female), 45HC (27 female)] completed rejection sensitivity, social anxiety, and emotion regulation (ER) measures. Preliminary analyses indicate EP initiate CU at a younger age and are at greater risk of developing CUD. 29% of EP and 0% of HC who endorsed CU in the prior 12 months met CUD criteria. Among individuals reporting cannabis as their primary substance, individuals with CUD were more likely to cite “to decrease anxiety/relax” as their primary reason for CU. Significantly more EP males endorsed CU, but no sex differences emerged amongst participants with CUD. Increased rejection sensitivity was associated with increased risk of developing CUD in males (r=0.54, p=0.03) and decreased risk in females (r=-0.46, p=0.08). Results demonstrate importance of examining sex effects in CU. Future analyses will examine CUD and ER relationships.