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175. The additive effect of trauma on cognitive control of emotion and symptom severity in individuals with schizophrenia and non-psychiatric controls
In individuals with schizophrenia (SZ), trauma exposure is prevalent (65-85%) and associated with worse symptoms. Impaired cognitive control of emotion (CCoE) is well-documented in both trauma-exposed and SZ populations, and related to symptom exacerbation. We hypothesized comorbid trauma has an additive effect on CCoE impairments and, consequently, symptom severity in SZ. Twenty-three SZ (14 female) and forty-four non-psychiatric control (NPC; 26 female) participants completed measures of demographics, trauma history (chart review, PCL-5), implicit CCoE (Multi-Source Interference Task-Emotion), explicit CCoE (Social Evaluation Task), positive, negative, and mood symptoms (BPRS, CAINS, BDI, BAI, LSAS), and emotion regulation (CERQ). Preliminary analyses indicated no sex differences in trauma exposure (p=0.43). NPC reported more trauma exposure than SZ (p=0.03), possibly reflecting differences in trauma history evaluation methods (chart review vs. PCL-5). Individuals with SZ and trauma had more severe positive symptoms than SZ without trauma (p=0.04). Regardless of group, for individuals with trauma, implicit CCoE was worse (slower reaction times) than individuals without trauma (p=0.04), and worse implicit CCoE was associated with more severe positive and negative symptoms (ps<0.01). Preliminary results suggest trauma is associated with worse implicit CCoE regardless of group. Additional analyses will examine associations between group, trauma, explicit CCoE, and emotion regulation.