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Neurobehavioral Indicators of Risk for the Development and Familial Transmission of Internalizing, Externalizing, and Psychotic Psychopathology
Neurobehavioral deviations in key systems underlying control, reward, emotionality, and social processes are evident across varied forms of psychopathology, including internalizing, externalizing, and psychotic psychopathology. However, the extent to which such deviations precede and confer risk for the development of psychopathology remains less well established. In this symposium, we examine neurobehavioral risk, measured at multiple levels of analysis, for depression, substance misuse, aggression, and psychosis. Using powerful and informative study designs (prospective, high-risk, twin family samples) and diverse methods (behavioral observations, laboratory paradigms, ecological momentary assessment, electroencephalogram, neurocognitive measures, magnetic resonance imaging), these talks provide evidence of the important role of control, emotionality, and social processes for the intergenerational transmission and prediction of depression, substance misuse, aggression, and psychosis. We conclude with a discussion, led by Discussant Dr. Daniel Klein, of neurobehavioral indicators of risk, commonality and specificity of affected systems across varied forms of psychopathology, and potential mechanisms by which neurobehavioral deviations may contribute to the development and familial transmission of psychopathology.