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32. Exploring the Transdiagnostic Contribution of Affiliative Tendency and Inhibitory Control to Empirically-Derived Dimensions of Psychopathology in Children
Recent initiatives have focused on integrating transdiagnostic biobehavioral models of clinically-relevant processes with dimensional quantitative structural models of psychopathology. Investigation into specific coupling of risk factors may distinguish divergent trajectories underlying comorbidity and multifinality. Toward this effort, affiliative tendency (AFT) and inhibitory control (IC) processes hold particular promise as an extensive literature demonstrates these processes as transdiagnostic and stable across developmental stages and multiple methods of measurement. In a sample of 865 5-10-year-olds (Mage = 8.01 ± 1.65 years; 34.2% female) the current study probes the moderating risk of IC variation on low AFT in explanation of broad, empirically-derived dimensions of psychopathology (i.e., fear, distress, externalizing). Through the use of parent-reported low AFT, child-based neurocognitive performance and structural gray matter indicators of IC, and diagnostic interview-based psychopathology, the current study integrates across informants and modes of measurement to address the crucial issue of method variance in cross-domain assessment of clinical problems and underlying processes. Results are expected to show distinct moderating effects such that in combination with low AFT, high IC will predict distress symptoms specifically, whereas low IC will predict externalizing. All told, the present study aims to integrate general trait transdiagnostic risk factors with dimensional models of psychopathology.