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80. White Matter Connectivity in Emotional Distress Disorders
Previous research suggests that emotional distress disorders, such as depression, anxiety, and borderline personality disorder, could be related to altered functioning in key brain regions involved in emotional processing, including the amygdala and ventromedial prefrontal cortex (vmPFC). We have previously found that altered resting state functional connectivity between the amygdala and vmPFC was related to behavioral and emotional dysregulation in daily life in these disorders. However, to our knowledge, whether structural connectivity between these regions is associated with daily life dysregulation in these disorders has never been examined. The current study used diffusion tensor imaging (DTI) to examine white matter amygdala-vmPFC connectivity in a sample of 27 women in current treatment for emotional distress disorders. We will examine the extent to which amygdala-vmPFC white matter tract integrity is associated with resting state connectivity in these disorders. Participants also completed two weeks of ambulatory assessment to assess daily life dysregulation. We will then also examine how white matter connectivity is related to measures of emotional and behavioral dysregulation in this sample. Hence, this study will contribute to our understanding of how structural connectivity is related to altered functional connectivity and daily life dysregulation in emotional distress disorders.