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64. EEG Reactivity in Response to Sham Feedback Across the Schizoaffective-Spectrum
The current categorical distinctions between schizophrenia and bipolar disorder perform poorly with mixed affective and psychotic symptom profiles. The common presentation of these mixed features, along with new genetic evidence, provide support for an alternative paradigm termed the schizoaffective-spectrum. However, a portion of individuals display prototypical symptom profiles distinct from mixed presentations that might be associated with unique pathophysiology. For example, individuals with non-affective psychosis appear to be more reactive to negative feedback, whereas, individuals who experience mania appear to be more reactive to anticipated positive feedback. Yet, little is known about the relationship of these variables in those with subclinical mood and psychosis-like traits (e.g., schizotypy, hypomania, and mixed). The current study sought to examine EEG reactivity to negative and positive feedback in participants grouped according to the presence of subclinical features. Preliminary findings indicate evidence for greater reward-oriented reactivity in the pure hypomania and mixed symptomatology groups when compared to pure schizotypy and control groups. Contrary to predictions, the pure schizotypy group had lower reactivity to negative feedback compared to the hypomania and mixed groups. The current study may help identify unique and shared features of these spectrum-disorders that may contribute to more targeted and effective early interventions.