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Thirty-Third Annual Meeting of the Society for Research in Psychopathology

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136. Investigating the relationship between paracingulate sulcus length and verbal source monitoring in clinical high risk for psychosis individuals

Reduced PCS length is associated with hallucinations in schizophrenia and with source misattribution in healthy individuals experiencing auditory perceptual disturbances, suggesting it may play a role in reality monitoring. However, the relationship between PCS length and reality monitoring has not been examined in clinical high risk for psychosis (CHRp). 55 CHRp individuals were identified using the Structured Interview of Psychosis-risk Symptoms. To measure reality monitoring, this study used a source memory task in which subjects read 72 sentences, half of which they completed and half of which had a response provided. Participants then indicated each response’s source during a recall phase. We acquired structural MRI images and the PCS was traced and categorized into prominent, present and absent using a standardized protocol. Participants had an 88.99% (11.4% SD) response accuracy with no significant differences between self- and other-generated words. There were no group differences in accuracy or reaction time across PCS categories and no significant relationships between task performance, PCS length, IQ or ratings of abnormal perceptual experiences. This suggests that PCS morphometry differences may not be significantly related to source monitoring impairment development or perceptual abnormalities in CHRp individuals. However, ceiling effects may be limiting results.

Austin Lee
Rush University Medical Center

Savannah Lokey
Rush University Medical Center

Kristen Haut
Rush University Medical Center

Sarah Pridgen
Rush University Medical Center

Christine Hooker
Rush University Medical Center

 


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