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138. The Structural Magnetic Resonance Imaging Correlates of Psychotic-Like Experience Subtypes
Accumulating evidence suggests that there are distinct neural correlates for positive psychotic symptom domains, yet research regarding such correlates among individuals reporting psychotic-like experiences (PLEs) has been limited. Thus, the aim of this study was to determine if PLE subtypes are related to gray matter volume (GMV) decreases in regions previously identified in the psychosis literature. Participants (n = 39) received MRIs and completed the Positive Symptom Subscale of the Prodromal Questionnaire, which was further categorized into three positive symptom dimensions: unusual/paranoid ideation, perceptual abnormalities, and disorganized communication. Images were preprocessed and analyzed using VBM software, and regional GMV was calculated using masks from the Wake Forest PickAtlas. Multivariate generalized linear models were used to assess the relationship between GMV in a number of ROIs and each of the PLE subtype dimensions while controlling for intracranial volume. Both disorganized communication and perceptual abnormalities were significantly associated with decreased volume in the left DLPFC. Unusual/paranoid ideation was not related to GMV differences in any region. These results suggest that disruptions in the DLPFC may contribute to experiences of subclinical perceptual aberrations and disorganized communication.