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140. Development of Hierarchical Dimensional Assessment for Thought Disorder
It has been shown that thought disorder is a general construct that comprises specific facets of hallucinations/delusions, disorganization, avolition, inexpressivity, and dissociation. However, there are currently no comprehensive dimensional assessments of these traits. We report the development of a self-report measure consistent with the Hierarchical Taxonomy of Psychopathology (HiTOP) dimensional framework for thought disorder. The Genomic Psychiatric Cohort (GPC) is a sample of 30,000 individuals diagnosed with psychotic disorders, ascertained from multiple sites across the United States and Pacific Islands. Seventy-nine participants have completed the item bank at the time of writing, with a target enrollment of 200. Participants have a mean age of 54.46 [range 30-78], and are 51.9% male. The sample is a majority Caucasian (86%), 7.6% African American, 3.8% unknown, and 2.5% multiracial. Diagnostic rates are schizophrenia (36.7%), bipolar (36.7%), schizoaffective disorder (12.7%), major depressive disorder (5%), substance induced psychosis (5%), and psychosis not otherwise specified (3.8%). The first phase of data analysis aims to reduce item redundancy by removing highly correlated items. The second phase focuses on reducing construct redundancy using an iterative factor analytic approach, and eliminating highly correlated factors. Psychometric characteristics of the resulting scales in this sample are reported.