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149. Errant Visual Processing and Real-World Perceptual Abnormalities Tied to Genetic Liability for Schizophrenia
Visual perceptual anomalies are reliably associated with schizophrenia, and may mark genetic liability for psychosis. Yet, the visual perceptual functions underlying these abnormalities remain equivocal. To better understand the basis of aberrant real-world perceptions in psychosis, we recruited people with schizophrenia (PSZ) and their first-degree relatives (PSZRel), and gathered neural and behavioral data by employing visual perceptual tasks tapping low to high levels of visual processing. We then compared performance on these tasks to self-reported deviant perception in daily experiences. A greater degree of real-world perceptual abnormalities was related to diminished performance on a high-level object discrimination task (DS-CPT) in PSZRel, but not PSZ. Future analyses will examine how low- and mid-level deficits in visual processing contribute to visual perceptual anomalies, and how the expression of genetic liability for schizophrenia influences related visual neural functions. A more precise understanding of neural mechanisms underlying visual perceptual anomalies indexing genetic liability for schizophrenia would provide insight into underlying etiologic factors in the disorder.