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161. Associations between childhood trauma and hippocampal subfield/ amygdala nuclei volumes within adults with psychosis: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes-2 Study
Introduction: Childhood trauma has been associated with psychosis and has correlated with lower amygdala and hippocampal volumes. However, the relationship between childhood trauma, amygdala nuclei (AN), and hippocampal subfield (HSF) volumes has not been explored.
Methods: Freesurfer 6.0 processed T1 MPRAGEs and parcellated HSF and AN for adults with psychosis (n=306) and controls (n=201). A one-way analysis of variance assessed group differences on imaging measures and the Childhood Trauma Questionnaire-Short Form (CTQ-SF). Partial correlations assessed CTQ-SF and volume relationships using Kendall’s tau controlling for age, sex, race and site; additionally, imaging measures controlled for total intracranial volume.
Results: CTQ-SF scores were higher in probands than controls. Higher physical neglect was associated with lower left CA3 volume in controls (corrected p <.02); probands had trending relationships with lower bilateral subiculum, left CA4, and right dentate gyrus. Before correction, greater emotional neglect was associated with lower right basal volume in controls; greater emotional and physical neglect were associated with lower right basal and accessory basal nuclei in probands.
Conclusion: Physical and emotional neglect may contribute differently to AN and HSF reductions in psychosis compared to controls. Future directions will investigate these relationships between Black Americans with psychosis and controls.