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Thirty-Third Annual Meeting of the Society for Research in Psychopathology

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161. Associations between childhood trauma and hippocampal subfield/ amygdala nuclei volumes within adults with psychosis: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes-2 Study

Introduction: Childhood trauma has been associated with psychosis and has correlated with lower amygdala and hippocampal volumes. However, the relationship between childhood trauma, amygdala nuclei (AN), and hippocampal subfield (HSF) volumes has not been explored.

Methods: Freesurfer 6.0 processed T1 MPRAGEs and parcellated HSF and AN for adults with psychosis (n=306) and controls (n=201). A one-way analysis of variance assessed group differences on imaging measures and the Childhood Trauma Questionnaire-Short Form (CTQ-SF). Partial correlations assessed CTQ-SF and volume relationships using Kendall’s tau controlling for age, sex, race and site; additionally, imaging measures controlled for total intracranial volume.

Results: CTQ-SF scores were higher in probands than controls. Higher physical neglect was associated with lower left CA3 volume in controls (corrected p <.02); probands had trending relationships with lower bilateral subiculum, left CA4, and right dentate gyrus. Before correction, greater emotional neglect was associated with lower right basal volume in controls; greater emotional and physical neglect were associated with lower right basal and accessory basal nuclei in probands.

Conclusion: Physical and emotional neglect may contribute differently to AN and HSF reductions in psychosis compared to controls. Future directions will investigate these relationships between Black Americans with psychosis and controls.

Aliyah Sanders
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA

Olivia Lutz
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA

Rachal Hegde
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA

Dung Hoang
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA

Philip Henson
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA

Emily Kline
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA

Godfrey Pearlson
Department of Psychiatry, Yale University, New Haven, CT

Brett Clementz
Department of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens, GA

Carol Tamminga
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX

John Sweeney
Department of Psychiatry, University of Cincinnati, Cincinnati, OH

Matcheri Keshavan
Department of Psychiatry, Harvard Medical School, Boston, MA

 


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