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30. Effects of early life stress and social resources on neurocognitive functions: A large replication study
Early life stress (ELS) has been associated with psychological and neural alterations in several domains including emotion processing, reward processing, working memory, and impulsivity. However, many prior studies included only a small number of participants, and there is a need to examine whether the findings will be generalized to different samples and situations. Here, we aimed to replicate the findings with a large sample, 1683 children from the Adolescent Brain Cognitive Development (ABCD) project. Additionally, we examined whether negative ELS effects can be modulated by social support outside the household. Consistent with prior findings, ELS was positively correlated with self-reported impulsivity and fMRI response in the amygdala and the insula while processing negative emotion and reward feedback, respectively. However, we also observed that several findings significantly related to ELS became non-significant after rigorously controlling for additional demographic variables. At the same time, with the large sample, we found novel effects of ELS in reward processing and the moderating effects of social resources on impulsivity.