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167. Proactive inhibition impairment in schizophrenia
Inhibitory control is a core cognitive deficit in schizophrenia, often measured through response inhibition tasks. However, it is unclear if both components of response inhibition, proactive inhibition and reactive inhibition, are both affected. We used archival data of 34 South African individuals with first-episode schizophrenia and 33 non-psychiatric controls. These participants completed the Stop-Signal Anticipation Task (SSAT; Zandbelt & Vink, 2010) as a measure of behavioral and brain imaging indices of response inhibition and the Positive and Negative Syndrome Scale (PANSS) as a measure of schizophrenia symptoms. Results yielded significant differences in behavioral and functional neuroimaging measures of proactive inhibition, and not reactive inhibition, between groups. Implications of these findings are discussed.