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101. Protective Effects of Prenatal Testosterone on Impulsivity and Loss of Control Eating in Adolescent Girls
Animal research suggests a protective effect of perinatal testosterone on binge eating in females; however, results in humans have been mixed. A potential reason for these equivocal findings might be that prenatal testosterone impacts traits that both decrease (e.g., sweet food preference) and amplify (e.g., impulsivity) risk for dysregulated eating. It may be that the protective effects of prenatal testosterone on dysregulated eating in humans will be more evident after controlling for the relationship between prenatal testosterone and impulsivity. Understanding the nuances of prenatal testosterone’s effects on dysregulated eating (e.g., binge eating and loss of control eating) has the potential to guide future etiological research. The present study will analyze relationships between measurements of index (2D):ring (4D) finger-length ratios (a biomarker of prenatal testosterone exposure), scores on a self-report measure of impulsivity (UPPS-P Impulsivity Behavior Scale), and scores on measures of dysregulated eating (e.g., Loss of Control Eating Disorder Version) in archival data from same-sex female twins (n=978). We plan to present our findings on whether the inverse relationship between prenatal testosterone exposure (represented by the 2D:4D ratio) and dysregulated eating is strengthened after accounting for prenatal testosterone’s effects on impulsivity.