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80. Anhedonia is uniquely associated with blunted reward-related neural activity during cue-evaluation
Prior functional magnetic resonance imaging (fMRI) research indicates that anhedonia is associated with blunted reward-related neural activity during reward anticipation. However, fMRI is limited by low temporal resolution and cannot differentiate between temporally distinct stages of reward anticipation: cue-evaluation, motor-preparation, and feedback-anticipation. In contrast, event-related potential (ERP) studies are well-suited to decompose the heterogeneity of reward anticipation. Although many ERP studies have found that anhedonia is associated with blunted feedback processing, far less ERP work has explored associations within each stage of reward anticipation. To address this gap, 69 young-adults from the Chicago area completed an electrophysiological monetary incentive delay task. Participants were prescreened to capture the full spectrum of threat and reward sensitivity. Cues before each trial indicated whether money was or was not available. Consistent with prior research, the P300 after money cues was significantly more positive than no-money cues, remaining significant up to 1s. Furthermore, self-reported anhedonia was significantly associated with blunted reward-related variation in the P300 and also remained significant up to 1s. This association did not emerge for reward-related ERPs during motor-preparation or feedback-anticipation, suggesting the association between anhedonia and blunted reward-related neural activity may be specific to the cue-evaluation stage of reward anticipation.